Christina Applegate’s Shocking MS Warning Came From an Unexpected Hollywood Star—You’ll Never Guess Who Spotted the Symptom First!
Added on May 9, 2025 inCelebrity News Cards
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Ever notice how sometimes life throws those cryptic curveballs when Mercury decides to throw a hissy fit in retrograde? Take Christina Applegate’s story, for instance. Just when you think the Hollywood hustle is all glitz and glam, bam—a fellow star spots a major symptom and nudges her to get checked for multiple sclerosis, that mysterious condition shadowing the brain and spinal cord. MS doesn’t exactly roll out the welcome mat; it creeps in with numbness, pain, and vision troubles—and no, the cosmic stars still haven’t fully cracked why it hits some folks. Christina, known for her sharp wit in Married… With Children and her saga in Dead to Me, found herself in this unexpected fraternity back in 2021. But here’s the kicker—she only got the push to seek answers because of Selma Blair, another star navigating the same storm, who spotted the signs early on. It makes you wonder—if the stars aligned differently, would she have caught it sooner? Or are some destinies just written in the restless dance of the planets? Dive into how friendship and fate intertwined in this tale of awareness, denial, and acceptance. LEARN MORE
Christina Applegate has revealed that she was urged to get checked for multiple sclerosis by another Hollywood star who’d noticed her exhibiting one major symptom.
Multiple sclerosis (MS) is a lifelong health condition which impacts the brain and spinal cord and causes pain, vision problems and numbness in the body. It’s currently unclear what causes MS and there is no cure for it.
Applegate, best known for her roles in Married… With Children and Dead to Me, Applegate was diagnosed with the neurodegenerative disease back in 2021.
Opening up on her early experience with the disease during a new interview with Conan O’Brien’s Conan O’Brien Needs a Friend podcast, the 53-year-old revealed it was actually another celebrity who realised her symptoms could be MS.
Christina Applegate is open about living with MS (Monica Schipper/WireImage)
When asked about her initial experience with MS, Applegate revealed her first symptoms were numbness in the toes, which occurred in January 2021.
“My toes weren’t feeling right,” she explained, adding: “Eventually, over those months it grew from my toes to my ankles… from my knees down.
“I was losing balance [and] the pain was extraordinary. When I say numb it’s numb but it hurts.”
Applegate then revealed the push to visit a neurologist about her symptoms came from Legally Blonde star Selma Blair. Like Applegate, Blair also has MS, having been diagnosed in 2018.
Recalling her response to Blair’s observations, she said: “I was like ‘No, there’s no way the both of us from the same movie have MS.”
Applegate’s diagnosis wouldn’t come until later on, when she had to pause filming for Dead to Me due to her worsening symptoms.
Christina Applegate and Selma Blair worked together on The Sweetest Thing (KMazur/WireImage)
“What’s interesting is that I look back over time and probably for like six years I was having weird things happening,” she continued. “Fluorescent lights would bother me… being up on a platform I would get afraid of heights.”
Blair has also recalled her experience of noticing the initial symptoms of MS in Applegate, telling People Magazine that she noticed the changes in her The Sweetest Thing co-star during a playdate for their children.
“I was noticing the symptoms when she was over,” she recalled. “I was like, ‘You’ve got to get an MRI.’ She did.”
Like Applegate, Blair has also been candid about what living with MS is like, revealing in a 2022 essay for The Guardian that she was urged not to go public with her diagnosis.
“My doctors urged me not to go public,” she penned. “They said people wouldn’t understand my diagnosis. They worried I wouldn’t get work.
“They said the disease might not progress beyond what I’d already experienced, so why share it?”
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